M.S. 医药科学


课程

 

课程描述

论文 Track 

第一年下降

 

第一年春天

Code

的名字

学分

 

Code

的名字

学分

PSC 631

药理学基础

3

 

 XXX

*必修课程-可从列表中选择

 

 

 


 

3

610年乙

伦理研究

1

 

PSC 651

药学杂志俱乐部

1

PSC 672

实验设计与数据分析

2

 

XXX

 

*必修课程-可从列表中选择


 

3

PSC 661

研究旋转

2

 

PSC 761

论文研究

3

PSC 651

药学杂志俱乐部

1

 

 

 

 

总学分

9

 

总学分

10

第二年秋天

 

 

第二年春天

 

XXX

选修

3

 

XXX

选修

3

XXX

选修

3

 

PSC 761

论文研究

2

PSC 761

论文研究

3

 

 

 

总学分

9

 

总学分

5

 Non-Thesis Track 

第一年下降

 

第一年春天

Code

的名字

学分

 

Code

的名字

学分

PSC 631

药理学基础

3

 

XXX

 

*必修课程-可从列表中选择

3

610年乙

伦理研究

1

 

PSC 651

药学杂志俱乐部

1

PSC 672

实验设计与数据分析

2

 

XXX

 

*必修课程-可从列表中选择

3

XXX

选修

2

 

XXX

选修

2

PSC 651

药学杂志俱乐部

1

 

 

 

 

总学分

9

 

总学分

9

第二年秋天

 

第二年春天

XXX

选修

3

 

XXX

选修(s)

3

XXX

选修

3

 

PSC 750

顶石

3

XXX

选修

3

 

 

 

总学分

9

 

总学分

6

可打印版本

课程描述

药物科学基础(PSC 631)
The course reviews the foundational topics in 药理学, pharmaceutics, and 药物化学. 涵盖的主题包括受体-配体相互作用的原理, 剂量反应曲线, 药物动力学(吸收, 分布, 以及消除药物), 结构活性关系, 药效学(药物浓度与作用), 药物的生物转化和影响药物作用的因素, 药物受体相互作用的计算建模原理, 合理药物设计. (3学分) 先决条件: CHE 312 or PSC 311; PSC 321/322.

研究伦理学(610年乙) 
这门课 includes a discussion format based on ethical issues involved in the research process. 学生 will have focused reading on the ethical issues involved in research and then will apply the readings to case studies during discussion. 涵盖的主题包括, 但不限于:道德和研究伦理, 伦理问题摆在研究委员会面前, 涉及人类和动物的伦理问题, 报告研究和利益冲突. (1).

实验设计与数据分析(psc672) 
这门课 is required for all 医药科学 graduate students and provides students with a basic knowledge of experimental design and biostatistics. 学生将学习如何设计实验和分析结果. 本课程将包括单因素实验, 多种因素, 全析因设计和部分析因设计以及筛选设计, 假设检验和相关生物统计学的基本原理. (2学分).

研究轮调(psc661) 
学生 will complete a one semester laboratory rotation in order to facilitate the selection of a thesis research advisor. 学生 select a potential mentor based on interests and availability of openings in any given lab. 作业, 根据学生的喜好, 将由药理学研究生项目主任. 学生 are expected to spend a minimum of 10 hours per week on laboratory research during the rotation. 学生 complete a rotation through a minimum of 1 lab and a maximum of 2 labs during the semester. They are to meet with the faculty advisor at least one hour per week for basic introduction to laboratory principles and practices, 讨论他们的研究. 学生 are required to complete reading assignments as directed by the faculty advisor and write a report of the research data and present a ten minute talk summarizing their research at the end of the rotation. (2学分).

药学杂志俱乐部(PSC 651) 
这门课, 这是所有药学研究生的必修课程, is designed to enhance the ability of graduate students to critically 评估 scientific articles published in juried scientific journals. Articles will be selected from current scientific literature in a variety of disciplines in the pharmaceutical sciences, 包括药物输送, 药物开发, 药物化学, 分子生物学, 药物基因组学, 药理学, 生理学, 生物化学和制药学. 所有参与者将阅读并评论文章. 每个学生每学期至少要提交两篇文章. (1)

Required courses (6 credits) can be selected from the following list of courses marked with an asterisk.

信号转导的药理调节(PSC 635) 
这门课 focuses on signaling pathways that transfer signals across cell membranes and within the cell and allow for regulation and integration of all aspects of cell function. 关键信号分子, 包括受体, g, 第二信使, 和转录因子, 以及小分子配体, 催化剂和抑制剂, 将检查.  Concepts and methodologies that have facilitated elucidation of the function of these molecules will be introduced through discussion of past and current landmark papers.  The goal of the course is to provide students with a fundamental 理解ing of signaling pathway function and regulation. This 理解ing will be placed in the context of drug action through examination of examples of a variety of drugs which act via modification of signaling pathways. (3学分) 先决条件: PSC 431/631或同等水平.

*药物输送原则(PSC 645) 
The course studies physicochemical and biological principles of drug delivery and pharmaceutical product design. These principles of physical pharmacy and biopharmaceutics are the foundations for drug candidate selection, pre-formulation, 配方设计, 还有药物输送系统. Targeted drug delivery and advanced systems for various routes of administration are also discussed by case studies. (3学分)  先决条件: PSC 341/342或PSC 431/631或同等水平.

*规管科学导论(PSC 646)
监管科学是开发新工具的科学, 评估安全的标准和方法, 功效, 质量, 及产品性能, 根据美国FDA的定义. The course begins with introducing the history and current status of the US federal regulatory system and the FDA. 随着课程的进行, 重点将放在该法律的结构和结果上, 监管策略, 全球化问题与这一新兴领域的伦理困境, 使用案例和讨论,参与主动学习. (3学分)  先决条件: PSC341 Pharmaceutics I, PSC641 Advanced Pharmaceutics I, or equivalent, and permission of instructor.

药代动力学建模(PSC 741) 
The course presents concepts and mathematical techniques for description of the time course of drug disposition in biological systems. 本课程也介绍在选择中使用的生物制药和药代动力学原理, 剂量, 药物治疗的监测和评估. 在课程结束时,学生应该能够找到, 获得, 理解, 分析, 评估, 并合成药代动力学信息, 理性的, 负责任的药物给药方案评估. (3学分)  先决条件: PSC 645或导师许可.

癌症药理学和分子遗传学(PSC 733
肿瘤发生的分子遗传机制的研究, 包括致癌基因的作用, 肿瘤抑制, 还有病原体(病毒和细菌). Genomic approaches to the study of both hereditary cancers and somatic mutations will be explored. The 药理学 of current cancer therapeutics and the 理性的 design of novel anti-cancer drugs will be discussed throughout the course. (3学分)  先决条件: PSC 631或导师的许可.

*药物定量设计(PSC 757)
The principles of subcellular pharmacokinetics are combined with the methods for estimation of drug-receptor binding energies for known and unknown receptors to provide a comprehensive quantitative approach to the construction of 结构活性关系. The emphasis is placed on 理解ing the principles of quantitative descriptions of absorption, 分布, 代谢和排泄以及药物结构和性质方面的药物受体结合. 药物理化性质的预测方法, 在药物开发中哪些是重要的, 详细分析. (3学分)

*分子建模(PSC 758)
在这门课, students will gain hands-on experience with the molecular modeling software that is used in pharmaceutical industry.  The following operations with protein structures will be learned: adding missing hydrogens to X-ray structures, 给氨基酸残基分配适当的电荷, 中和电荷并为药物对接准备结构. 所获得的技能将包括绘制分子结构草图, 将它们与大分子目标对接,并进行简单的结合能预测. (3学分).

*大分子结构(psc760)
这门课 will cover the fundamentals of macromolecular structure from the biochemistry of amino acids to protein motifs and folds, 四级结构, 翻译后修饰和蛋白质-蛋白质相互作用.  通博app下载将介绍可用于收集蛋白质结构信息的技术(NMR), circular dichroism and X-ray crystallography) and methods used to investigate the interaction of proteins with other molecules (tryptophan fluorescence, 等温滴定量热法, NMR). 本课程将使学生熟悉包括BLAST在内的蛋白质组学工具, Pymol, PDB and Expasy and will provide students with the tools necessary to make connections between the structure and function, 推断未知蛋白质的信息. (3学分).

论文研究(PSC 761) 
本课程包括一个由学生设计的独立研究项目, 咨询论文导师. 确定论文指导老师和论文委员会. 然后,学生将提出一份论文提案,由论文委员会批准. 一旦工作描述在论文开题已经完成, 学生将撰写论文并进行答辩. 预计论文研究将在2-3个学期内完成. (1 - 8学分).

750年顶石(PSC)
本课程只对非论文跟踪学生开放. 总结性写作项目是一个独立的学习课程. 学生 will select a topic in conjunction with the faculty instructor and prepare a written review of the existing scientific literature that is relevant to the chosen topic. The review should focus on a particular scientific problem that is actively being investigated and should define and discuss the scope of the problem, 这些办法所产生的实质性结果, 以及这些发现如何塑造了目前对这一问题的认识. (3学分) 先决条件:教师许可.